Would you like to change to the United States site? Harald zur Hausen.
Professor zur Hausen has been a member of various research organizations, academies of science, and scientific boards. Harald zur Hausen is on the editorial board of several scientific journals and serves as Editor-in-Chief of the International Journal of Cancer , published by Wiley-Blackwell on behalf of the International Union Against Cancer. Professor zur Hausen has organized or co-organized a number of international meetings.
He was recognized "for his discovery of human papilloma viruses causing cervical cancer. Fox, Timothy C.
Significance of Infectious Agents in Colorectal Cancer Development
Wang, and Julie Parsonnet. Undetected location. NO YES. Infections Causing Human Cancer.
Selected type: E-Book. Added to Your Shopping Cart. Conjecture based on theoretical is no substitute for proof based on reliable and valid scientific research. This is a thoughtful overview of this newly-discovered virus. In terms of molecular measures of causation, I quibble with Dr. Racaniello on whether immortalization of cells by a virus or its DNA is the defining evidence needed to determine if it is a cancer virus.
Many viruses and gene fragments can immortalize cells in culture e. On the other hand, some cancer-causing genes e. These assays have been helpful in assessing viral carcinogenicity, they can only be used as rough molecular guides to understanding viral carcinogenesis. They have been used by some scientists as intellectual straight-jackets rather than important but imperfect tools. Instead, the most telling evidence that a virus causes cancer is human cancer epidemiology itself—as alluded to RYoerge's reference of some of the pioneers in epidemiologic causation.
I disagree, however, with most of this comment since there is no substitute for at least casually looking at the primary scientific literature. Causation is a normative exercise but rather than restating AB Hill's criteria, or another formalism, I would like to respond to this comment by restating points made in the essay:. These mutations may arise from sun-exposure—although this is not known for certain.
No intact, unmutated helper viruses have been found in these tumors. These mutations eliminate the ability of the virus to replicate by truncating its helicase and therefore the virus is not a passenger virus. The MCV virions from Wetzels et al, PLoS One shown in the electon micrograph picture on this diary are probably empty-capsid, self-assembling virus-like particles from expression of the VP1 gene of integrated MCV rather than replicating and transmissible virus see Tolstov et al.
Int J Cancer It also remains possible, however, that a minority of tumors retain unintegrated, episomal virus as is the case for some genotypes of HPV in cervical cancer. RYoerge's comment suggesting that MCV is an poorly-examined human rumor virus does not hold water. The virus has been rigorously examined and I highly respect my colleagues' rapid progress in describing this agent in a little over a year. As of today May 26, there are 26 primary data articles on MCV detection in Merkel cell carcinoma in the PubMed database and almost as many reviews.
To date, there is no data that I am aware of suggesting that the virus is not the cause of most Merkel cell carcinomas.
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This is just the beginning phase for studies on this virus and I hope that RYeorge will continue look at this data and give new opinions on it. Whether other diseases and cancers are caused by this virus is unknown, but MCV and Merkel cell carcinoma is already well-trod ground as can be seen in a simple PubMed search.
It's a growing body of literature that I for one am proud to have contributed to. Next post: Reverse zoonoses: Human viruses that infect other animals.
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